反应详情

In a 50 mL volume glass flask equipped with a stirrer, a thermometer and a reflux condenser were placed 1.01 g (3.29 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 0.5 g of 10 wt. % palladium/carbon, and 10 mL of formic acid. The reaction was carried out at 60° C. for 8 hours. After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.78 g (reaction yield: 87.0%) of methyl 5-methoxy-4-(3-chloropropoxy)-anthranilate.

1. customIn a 50 mL volume glass flask equipped with a stirrer
2. filtrationthe reaction mixture was filtered