Hydrochloric Acid → HCID 67119408, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-4-methyl-5-(4-(trifluoromethoxy)phenoxy)benzoate (3.69 g), 20 ml of xylene, 5.3 ml of 3-pentanone, and 0.256 g of zinc chloride were added into a 50-ml glass flask equipped with a stirring device, a thermometer, a reflux condenser, and a Dean-Stark device under a nitrogen atmosphere, and the temperature was raised to reflux with stirring. A reaction was allowed to proceed for 50 hr while adding 1.1 g of zinc chloride in four divided portions. After the completion of the reaction, the mixture was cooled to 70° C., and 10 ml of 0.1 N hydrochloric acid was added to the cooled solution, followed by cooling to room temperature. The precipitated solid was collected on a suction filter, was washed with an aqueous methanol solution and distilled water, and was dried to give 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinolin-4(1H)-one as a light brown solid (3.29 g, yield: 87.3%).

Provenance & Evidence