Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Methyl 4-bromo-3,5-diethoxybenzoate | HCID 57930905 | — |
| Reactant | [5-(tert-Butoxycarbonyl)pyridin-3-yl]boronic acid | HCID 58208715 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 67055612 | HCID 67055612 | — |
Reaction Steps
H2O (59.4 mg, 3.30 mmol) was added to a stirred suspension of PdCl2(dppf) (12.1 mg, 0.0330 mmol), methyl 4-bromo-3,5-diethoxybenzoate (200 mg, 0.660 mmol), [5-(tert-butoxycarbonyl)pyridin-3-yl]boronic acid (177 mg, 0.792 mmol) and K3PO4 (420 mg, 1.98 mmol) in DME (4 ml) and the mixture was stirred at 90° C. overnight. The reaction mixture was filtered through celite pad, the filtrate was concentrated under reduced pressure. The residue was purified by silicagel column chromatography (hexane/EtOAc) to give intended compounds as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08524730B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-49de55c05d7840eba97ada2ce82f42a6 |
|---|
| Source note | uspto-grants-2013_09 |
|---|
