3-(5-Methoxy-1H-indol-3-yl)propanoic acid → HCID 18449999, compound

HRID 384864Notes

Reaction equation

HRID 384864 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][C:14]([OH:16])=[O:15].[S:17]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([S:22]([C:19]1[CH:20]=[CH:21][S:17][CH:18]=1)(=[O:24])=[O:23])[CH:7]=[C:6]2[CH2:12][CH2:13][C:14]([OH:16])=[O:15]

Participants

3

Reactant 2

HCID 1811373-(5-Methoxy-1H-indol-3-yl)propanoic acidHCID 2776378Thiophene-3-sulfonyl Chloride

Product 1

HCID 18449999HCID 18449999, compound

Procedure

3-[5-Methoxy-1-(thiophene-3-sulfonyl)-1H-indol-3-yl]-propionic acid 99 was prepared from 3-(5-methoxy-1H-indol-3-yl)-propionic acid 96 and 3-thienyl-sulfonyl chloride using the same protocol as described in step 8, Example 4. (M−1, 364.4)

Sources & evidence

ORD record
ord-5dd93b86e8c843e7be98d8a3a23ca4a3
Source dataset
uspto-grants-2013_02
Patent number
US08367828B2

Reaction notes

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