Sodium Hydroxide → HCID 178434289, compound

HRID 38487Notes

Reaction equation

HRID 38487 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[NH:6][N:5]=1>CO>[CH3:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=2)[NH:6][N:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178497389HCID 178497389, compound

Product 1

HCID 178434289HCID 178434289, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

Aqueous 5N NaOH (4 ml, 20.00 mmol) was added to a stirred solution of methyl 3-methyl-1H-indazole-5-carboxylate (1.02 g, 5.36 mmol) in MeOH (10 ml) and the mixture was stirred at 70° C. for 6 h. The mixture was cooled, and the solvent was evaporated under reduced pressure. The mixture was diluted with H2O, and aqueous 5N HCl (4 ml) was added to the mixture with stirring, the resulted precipitate was filtered and dried over at 50° C. overnight to give intended compound as a brown solid.

Workup

  1. temperatureThe mixture was cooled
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe mixture was diluted with H2O, and aqueous 5N HCl (4 ml)
  4. additionwas added to the mixture
  5. stirringwith stirring
  6. filtrationthe resulted precipitate was filtered
  7. customdried over at 50° C. overnight
  8. customto give

Sources & evidence

ORD record
ord-30aaf3f60f174e979b3dae98c7dbe59b
Source dataset
uspto-grants-2013_09
Patent number
US08524730B2

Reaction notes

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