3-Furanol, tetrahydro- → 5-Bromo-4-methyl-2-(oxolan-3-yloxy)pyridine

HRID 384883Notes

Reaction equation

HRID 384883 reaction equation
[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.O[CH:11]1[CH2:15][CH2:14][O:13][CH2:12]1>>[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([O:8][CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 178429280HCID 178429280, compound

Product 1

HCID 684099505-Bromo-4-methyl-2-(oxolan-3-yloxy)pyridine

Procedure

The title compound was prepared from 5-bromo-2-hydroxy-4-methylpyridine and rac-3-hydroxy-tetrahydrofuran in analogy to Example 9c): colorless liquid.

Sources & evidence

ORD record
ord-4e03017035f54862b15fe2e4f5e1896d
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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