HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Fluoropyridin-3-yl)boronic acid → Rac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-2-methoxy-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Fluoropyridin-3-yl)boronic acid | HCID 44717403 | — |
| Reactant | Rac-[2-(4-bromo-2-methoxy-phenyl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68408611 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-2-methoxy-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410960 | — |
Reaction Steps
The title compound was prepared rac-[2-(4-bromo-2-methoxy-phenyl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 5-fluoropyridine-3-boronic acid in analogy to Example 1b): MS (ISP): 507.4 (M+H)+ (100%) and 522.7 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-bc62dc2fdb2d4c38b515d83293aea620 |
| Source note | uspto-grants-2013_02 |