HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Fluoropyridin-3-yl)boronic acid → Rac-[1-(3,4-dichloro-phenyl)-2-(5'-fluoro-[3,3']bipyridinyl-6-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Fluoropyridin-3-yl)boronic acid | HCID 44717403 | — |
| Reactant | Rac-[2-(5-bromo-pyridin-2-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68409891 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-(5'-fluoro-[3,3']bipyridinyl-6-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410622 | — |
Reaction Steps
The title compound was prepared from rac-[2-(5-bromo-pyridin-2-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 5-fluoropyridine-3-boronic acid in analogy to Example 1b): MS (ISP): 476.1 and 478.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-38524549be2d4d7e8616dbbf1ae4f19a |
| Source note | uspto-grants-2013_02 |