HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-2-methyl-6-((tetrahydrofuran-3-yl)oxy)pyridine → Rac-[1-(3,4-dichloro-phenyl)-2-[2-methyl-6-(tetrahydro-furan-3-yloxy)-pyridin-3-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-2-methyl-6-((tetrahydrofuran-3-yl)oxy)pyridine | HCID 68409329 | — |
| Reactant | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-[2-methyl-6-(tetrahydro-furan-3-yloxy)-pyridin-3-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410380 | — |
Reaction Steps
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and rac-3-bromo-2-methyl-6-(tetrahydro-furan-3-yloxy)-pyridine (Intermediate 13) in analogy to Example 1a): MS (ISP): 481.2 (M+H)+ and 483.2 ((M-Boc)+H)+ (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ee1d9f95040d4a51bf0436a440a9bfbf |
| Source note | uspto-grants-2013_02 |