HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran → Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran | HCID 68409276 | — |
| Reactant | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410060 | — |
Reaction Steps
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran (Intermediate 18) in analogy to Example 1a): MS (ISP): 516.1 and 518.1 (M+H)+, 416.2 and 418.0 ((M-Boc)+H)+ (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-abe192268957436c848b09cf772c0fa4 |
| Source note | uspto-grants-2013_02 |