HCID 59277464, compound → HCID 68409971, compound

HRID 384921Notes

Reaction equation

HRID 384921 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[CH:27][N:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[CH:27][N:26]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 59277464HCID 59277464, compound2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 68409971HCID 68409971, compound

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 2-bromo-5-(tetrahydro-pyran-4-yloxy)-pyridine (Intermediate 23) in analogy to Example 1a): MS (ISP): 481.2 and 483.1 (M+H)+.

Sources & evidence

ORD record
ord-45788f73e1454c38b81135c549faa3a9
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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