HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-3-methyl-2-(oxan-4-yloxy)pyridine → Rac-[1-(3,4-dichloro-phenyl)-2-[5-methyl-6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-3-methyl-2-(oxan-4-yloxy)pyridine | HCID 68410626 | — |
| Reactant | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-[5-methyl-6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410256 | — |
Reaction Steps
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 5-bromo-3-methyl-2-(tetrahydro-pyran-4-yloxy)-pyridine (Intermediate 24) in analogy to Example 1a): MS (ISN): 493.1 and 495.2 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-64949418f50d49508111c0c056da692e |
| Source note | uspto-grants-2013_02 |