2-[(4-Bromo-3-fluorophenoxy)methyl]tetrahydrofuran → HCID 68408986, compound

HRID 384924Notes

Reaction equation

HRID 384924 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:37]=[CH:36][C:28]([O:29][CH2:30][CH:31]2[CH2:35][CH2:34][CH2:33][O:32]2)=[CH:27][C:26]=1[F:38]>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:37]=[CH:36][C:28]([O:29][CH2:30][CH:31]2[CH2:35][CH2:34][CH2:33][O:32]2)=[CH:27][C:26]=1[F:38])=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 652031072-[(4-Bromo-3-fluorophenoxy)methyl]tetrahydrofuran2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 68408986HCID 68408986, compound

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and rac-2-(4-bromo-3-fluoro-phenoxymethyl)-tetrahydro-furan (Intermediate 26) in analogy to Example 1a): colorless gum.

Sources & evidence

ORD record
ord-ff674ce2b0a545b4857a447e6fabd2fb
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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