HCID 68409002, compound → Rac-[1-(3,4-dichloro-phenyl)-2-[2-fluoro-4-(oxetan-2-yl-methoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384925Notes

Reaction equation

HRID 384925 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:36]=[CH:35][C:28]([O:29][CH2:30][CH:31]2[CH2:34][CH2:33][O:32]2)=[CH:27][C:26]=1[F:37]>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:36]=[CH:35][C:28]([O:29][CH2:30][CH:31]2[CH2:34][CH2:33][O:32]2)=[CH:27][C:26]=1[F:37])=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 68409002HCID 68409002, compound2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 68408978Rac-[1-(3,4-dichloro-phenyl)-2-[2-fluoro-4-(oxetan-2-yl-methoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and rac-2-(4-bromo-3-fluoro-phenoxymethyl)-oxetane (Intermediate 27) in analogy to Example 1a): colorless gum.

Sources & evidence

ORD record
ord-a365dafa68474568b272ded3eec7d412
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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