2-Bromo-5-[(propan-2-yl)oxy]pyridine → HCID 68408802, compound

HRID 384928Notes

Reaction equation

HRID 384928 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:27][N:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:30]=[CH:29][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:27][N:26]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 547754082-Bromo-5-[(propan-2-yl)oxy]pyridine2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 68408802HCID 68408802, compound

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 2-bromo-5-isopropoxy-pyridine (Intermediate 30) in analogy to Example 1a): MS (ISP): 439.2 and 441.1 (M+H)+, 383.2 and 385.1 ((M-isobutene)+H)+ (100%).

Sources & evidence

ORD record
ord-096619e59ce04c9baf05639ddb3b1164
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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