HCID 68412418, compound → HCID 68409937, compound

HRID 384930Notes

Reaction equation

HRID 384930 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:37]=[CH:36][C:28]([O:29][CH2:30][C:31]2([CH3:35])[CH2:34][O:33][CH2:32]2)=[CH:27][C:26]=1[F:38]>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:37]=[CH:36][C:28]([O:29][CH2:30][C:31]2([CH3:35])[CH2:34][O:33][CH2:32]2)=[CH:27][C:26]=1[F:38])=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 68412418HCID 68412418, compound2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 68409937HCID 68409937, compound

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 3-(4-bromo-3-fluoro-phenoxymethyl)-3-methyl-oxetane (Intermediate 32) in analogy to Example 1a): MS (ISP): 498.3 and 500.2 (M+H)+, 398.2 and 400.0 ((M-Boc)+H)+ (100%); MS (ISN): 496.4 and 498.5 (M−H)−.

Sources & evidence

ORD record
ord-3e26af07d396430ab579d06190d004d9
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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