4-(4-Iodophenoxy)oxane → HCID 75228883, compound

HRID 384934Notes

Reaction equation

HRID 384934 reaction equation
C(OC(=O)[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)(C)(C)C.I[C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[CH:27][CH:26]=1>>[NH2:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[CH:9]([C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)=[CH:27][CH:26]=1)[OH:14]

Participants

3

Reactant 2

HCID 242295244-(4-Iodophenoxy)oxaneHCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Product 1

HCID 75228883HCID 75228883, compound

Procedure

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-iodophenoxy)tetrahydropyran in analogy to Example 1a): MS (ISP): 480.2 and 482.1 (M+H)+, 424.1 and 426.0 ((M-isobutene)+H)+ (100%), 380.1 and 382.0 ((M-Boc)+H)+ (94%).

Sources & evidence

ORD record
ord-bd3d6f4845f14d8091a699a4c52423ec
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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