HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-2H-thiopyran-4-ol → Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(tetrahydro-thiopyran-4-yloxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-2H-thiopyran-4-ol | HCID 576296 | — |
| Reactant | Rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68409306 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(tetrahydro-thiopyran-4-yloxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester | HCID 68410681 | — |
Reaction Steps
The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and tetrahydro-2H-thiopyran-4-ol in analogy to Example 9c): MS (ISP): 496.2 and 498.1 (M+H)+, 396.1 and 397.9 ((M-Boc)+H)+ (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-72988a8d24ca4560921a3e352fe52cf0 |
| Source note | uspto-grants-2013_02 |