HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Hydroxypiperidin-1-yl)ethan-1-one → Rac-[2-[4-(1-acetyl-piperidin-4-yloxy)-phenyl]-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Hydroxypiperidin-1-yl)ethan-1-one | HCID 10749291 | — |
| Reactant | Rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68409306 | — |
| Product | Rac-[2-[4-(1-acetyl-piperidin-4-yloxy)-phenyl]-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68408625 | — |
Reaction Steps
The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 1-(4-hydroxy-piperidin-1-yl)-ethanone in analogy to Example 9c): MS (ISP): 521.2 and 523.2 (M+H)+; MS (ISN): 519.1 and 521.2 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-1b0c0ac965cc41689e53628bc3b35d45 |
| Source note | uspto-grants-2013_02 |