HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene → Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene | HCID 22913883 | — |
| Reactant | Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 87442373 | — |
| Product | Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester | HCID 68410008 | — |
Reaction Steps
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 1-bromo-4-(2,2,2-trifluoro-ethoxy)-benzene in analogy to Example 1a): MS (ISP): 478.1 and 480.1 (M+H)+, 378.2 and 380.0 ((M-Boc)+H)+ (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-b1df89d084304f269c5fab0e9f1d90f3 |
| Source note | uspto-grants-2013_02 |