3,3,3-Trifluoro-1-propanol → HCID 68408635, compound

HRID 384946Notes

Reaction equation

HRID 384946 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[F:27][C:28]([F:33])([F:32])[CH2:29][CH2:30]O>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9](=[O:10])[C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:30][CH2:29][C:28]([F:33])([F:32])[F:27])=[CH:15][CH:16]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 1375123,3,3-Trifluoro-1-propanolHCID 68409306Rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 68408635HCID 68408635, compound

Procedure

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 3,3,3-trifluoropropanol in analogy to Example 9c): MS (ISP): 492.2 and 494.2 (M+H)+, 392.0 and 394.0 ((M-Boc)+H)+ (100%).

Sources & evidence

ORD record
ord-0e9a38c2134b4c68acd134006a2d5bbe
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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