反应详情

1.54 g thieno(3,4-c)furan-1,3-dione and 1.42 g of 3-aminopiperidine-2,6-dione trifluoroacetic acid were dissolved in 15 mL of acetic acid. The reaction mixture was refluxed overnight, cooled, and evaporated to remove the solvent. The residue was dissolved in 20 mL anhydrous THF, and 2 g of CDI, and a catalytic quantity of DMAP were added. The reaction mixture was refluxed for 6 h until a large amount of white solid precipitated. The solid was cooled and filtered to yield 1.9 g of the title compound.

1. temperatureThe reaction mixture was refluxed overnight
2. temperaturecooled
3. customevaporated
4. customto remove the solvent
5. dissolutionThe residue was dissolved in 20 mL anhydrous THF
6. addition2 g of CDI, and a catalytic quantity of DMAP were added
7. temperatureThe reaction mixture was refluxed for 6 h until a large amount of white solid
8. customprecipitated
9. temperatureThe solid was cooled
10. filtrationfiltered