3-Furanol, tetrahydro- → HCID 68409250, compound

HRID 384950Notes

Reaction equation

HRID 384950 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].O[CH:28]1[CH2:32][CH2:31][O:30][CH2:29]1>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([Cl:25])[CH:19]=1)[C:9](=[O:10])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:28]2[CH2:32][CH2:31][O:30][CH2:29]2)=[CH:13][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 68409914HCID 68409914, compound

Product 1

HCID 68409250HCID 68409250, compound

Procedure

The title compound was prepared from rac-[1-(3-chloro-4-methyl-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and rac-3-hydroxy-tetrahydrofuran in analogy to Example 9c): MS (ISN): 444.3 (M−H)−.

Sources & evidence

ORD record
ord-d886dd90b46e4b108dcbc9c56a768a64
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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