HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Difluoro-2-propanol → Rac-[1-(4-chloro-phenyl)-2-[4-(2-fluoro-1-fluoromethyl-ethoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Difluoro-2-propanol | HCID 67985 | — |
| Reactant | Rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68409176 | — |
| Product | Rac-[1-(4-chloro-phenyl)-2-[4-(2-fluoro-1-fluoromethyl-ethoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester | HCID 68410284 | — |
Reaction Steps
The title compound was prepared from rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 1,3-difluoro-2-propanol in analogy to Example 9c): MS (ISN): 438.1 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-3b7a58a02e804656aa7022a1d21093a3 |
| Source note | uspto-grants-2013_02 |