p-Diiodobenzene → HCID 68408967, compound

HRID 384955Notes

Reaction equation

[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([F:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].[I:24][C:25]1[CH:30]=[CH:29][C:28](I)=[CH:27][CH:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([F:22])[CH:16]=1)[C:9]([C:28]1[CH:29]=[CH:30][C:25]([I:24])=[CH:26][CH:27]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 12208p-Diiodobenzene

HCID 87442638HCID 87442638, compound2×

Product 1

HCID 68408967HCID 68408967, compound

Procedure

The title compound was prepared from rac-[(4-chloro-3-fluoro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 1) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISN): 487.9 (M−H)− and 413.9 ((M-tBuOH)−H)−.

Sources & evidence

ORD record: ord-120cef684b9540189224390e6e7dab54
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367838B2

Reaction notes

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