p-Diiodobenzene → HCID 68409931, compound

HRID 384957Notes

Reaction equation

[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:19](=[O:24])N(OC)C)[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[I:26][C:27]1[CH:32]=[CH:31][C:30](I)=[CH:29][CH:28]=1>>[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:13][CH:14]=1)[C:19]([C:30]1[CH:31]=[CH:32][C:27]([I:26])=[CH:28][CH:29]=1)=[O:24])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 12208p-Diiodobenzene

HCID 87443436HCID 87443436, compound2×

Product 1

HCID 68409931HCID 68409931, compound

Procedure

The title compound was prepared from rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 10) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISN): 504.0 (M−H)−.

Sources & evidence

ORD record: ord-0aafa4a8d01e4a4ca10a7cabff38be61
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367838B2

Reaction notes

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