p-Diiodobenzene → HCID 68410404, compound

HRID 384961Notes

Reaction equation

HRID 384961 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([F:25])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].[I:27][C:28]1[CH:33]=[CH:32][C:31](I)=[CH:30][CH:29]=1>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[C:17]([F:25])[CH:16]=1)[C:9]([C:31]1[CH:32]=[CH:33][C:28]([I:27])=[CH:29][CH:30]=1)=[O:14])([CH3:3])([CH3:2])[CH3:4]

Participants

3

Reactant 2

HCID 12208p-DiiodobenzeneHCID 87442619HCID 87442619, compound2×

Product 1

HCID 68410404HCID 68410404, compound

Procedure

The title compound was prepared from rac-[(3-fluoro-4-trifluoromethyl-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 5) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISN): 522.1 (M−H)−.

Sources & evidence

ORD record
ord-a99db722c2ff495cb86176a91759dc79
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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