p-Diiodobenzene → HCID 68408866, compound

HRID 384962Notes

Reaction equation

[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[F:22])[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].[I:24][C:25]1[CH:30]=[CH:29][C:28](I)=[CH:27][CH:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[F:22])[C:9]([C:28]1[CH:29]=[CH:30][C:25]([I:24])=[CH:26][CH:27]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 12208p-Diiodobenzene

HCID 87443118HCID 87443118, compound2×

Product 1

HCID 68408866HCID 68408866, compound

Procedure

The title compound was prepared from rac-[(4-chloro-2-fluoro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 3) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISP): 489.9 (M+H)+.

Sources & evidence

ORD record: ord-0e5c23e8149d411da7f1f4e9c1387858
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367838B2

Reaction notes

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