HuagongsheHuagongshe Chemistry Print Report · For research reference only
Rac-1-bromo-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene → Rac-[1-(4-chloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Rac-1-bromo-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene | HCID 68408561 | — |
| Reactant | Rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester | HCID 71663866 | — |
| Product | Rac-[1-(4-chloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester | HCID 68409760 | — |
Reaction Steps
The title compound was prepared from rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 8) and rac-1-bromo-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene (Intermediate 35) in analogy to Example 1a): MS (ISP): 458.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367838B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-a339dd7dc2b946d989b6a0154580aafc |
| Source note | uspto-grants-2013_02 |