2-Fluoro-5-isopropoxyphenylboronic acid → HCID 68408610, compound

HRID 384968Notes

Reaction equation

HRID 384968 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14](I)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[F:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH:35]([CH3:37])[CH3:36])=[CH:30][C:29]=1B(O)O>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:33]2[CH:32]=[C:31]([O:34][CH:35]([CH3:36])[CH3:37])[CH:30]=[CH:29][C:28]=2[F:27])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 162176812-Fluoro-5-isopropoxyphenylboronic acidHCID 68409915Rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 68408610HCID 68408610, compound

Procedure

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 2-fluoro-5-isopropoxyphenylboronic acid in analogy to Example 2b): MS (ISP): 532.1 and 534.1 (M+H)+, 432.2 and 434.1 ((M-Boc)+H)+.

Sources & evidence

ORD record
ord-44fcc7ac92d34d6280b554a458e490b7
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Reaction notes

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