2-Chloroethanol → HCID 58102871, compound

Participants

Reaction Steps

To a solution of N-(4-bromophenyl)-1-(4-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide (30 mg, 0.071 mmol) in DMF (0.2 mL) was added K2CO3 (30 mg, 0.22 mmol) and 2-chloroethanol (9.3 uL, 0.14 mmol). The reaction mixture was heated at 70 C overnight. It was filtered and purified by prep HPLC to afford N-(4-bromophenyl)-1-(4-(2-hydroxyethoxy)-2,3-dihydro-1H-inden-1-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide (20 mg, 60%). Retention time (min)=7.588, method [7], MS (ESI) 469.1 (M+H); 1H NMR (300 MHz, CDCl3) δ 12.20 (s, 1H), 8.57 (dd, J=2.1 Hz, 6.9 Hz, 1H), 7.65 (d, J=9.0 Hz, 2H), 7.44 (d, J=9.0 Hz, 2H), 7.15-7.30 (overlap with CDCl3, 2H), 6.83 (d, J=8.1 Hz, 1H), 6.73 (d, J=7.5 Hz, 1H), 6.58 (dd, J=5.4 Hz, 8.4 Hz, 1H), 6.39 (t, J=6.9 Hz, 1H), 4.14 (m, 2H), 4.00 (m, 2H), 2.78-3.15 (m, 3H), 1.90-2.10 (m, 1H).

Provenance & Evidence