Sulfuryl chloride → HCID 49764778, compound

Participants

Reaction Steps

After dissolving 2.8 g of 2-(4-methylpentan-2-yl)-3-nitro-2,5-dihydrothiophene in 40 ml of dichloromethane, a solution prepared by dissolving 2.6 g of sulfuryl chloride in 5 ml of dichloromethane was added thereto, and the solution was stirred at room temperature for 1.5 hours. After adding an aqueous solution of saturated sodium bicarbonate, the solution was extracted with dichloromethane. The organic layer was washed with saturated saline, dried with magnesium sulfate and concentrated, and then purified by NH-silica gel chromatography (hexane/ethyl acetate=10/1), thereby obtaining 2.0 g of 2-(4-methylpentan-2-yl)-3-nitrothiophene (yield: 70.1%).

Provenance & Evidence