Hydrochloric Acid → HCID 15390172, compound

Participants

Reaction Conditions

Reaction Steps

After dissolving 0.33 g of 2-(4-methylpentan-2-yl)-3-nitrothiophene in 6 ml of ethanol, 0.88 g of tin chloride (II) and 0.97 g of concentrated hydrochloric acid were added thereto, and the reaction solution was heated to 70° C. and stirred for an hour. After cooling the solution to room temperature, 1 mol/l of an aqueous sodium hydroxide was added thereto, and the solution stirred for five minutes. The resultant was filtered on cellite, and the filterate was extracted with ethyl acetate. The organic layer was washed with 1 mol/l of aqueous sodium hydroxide and saturated saline. Then, the organic layer was dried with magnesium sulfate and concentrated, and then purified by silica gel chromatography (hexane/ethyl acetate=8/1), thereby obtaining 0.11 g of 2-(4-methylpentan-2-yl)-3-aminothiophene (yield: 39.0%).

Provenance & Evidence