HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385004Generated: October 31, 2026
Toluene → 3,5-Dichloro-4-methoxybenzoyl chloride
https://huagongshe.com/reaction/385004
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzoic acid, 3,5-dichloro-4-methoxy- | HCID 721135 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3,5-Dichloro-4-methoxybenzoyl chloride | HCID 3830315 | — |
Reaction Steps
To 3,5-dichloro-4-methoxybenzoic acid (8.81 g), toluene (170 mL), N,N-dimethylformamide (5 droplets) and thionyl chloride (6.0 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and then used for the synthesis of (c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-cab27125e60342dc9e9fc0a0a8f997f1 |
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| Source note | uspto-grants-2013_02 |
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