Hydrochloric Acid → HCID 68109266, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-cyano-4-methoxy-5-trifluoromethylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (4.08 g) was dissolved in N,N-dimethylformamide (40 mL), and lithium chloride (1.74 g) was added to the solution, and then the mixture was stirred at 70° C. for 2 hours. To the reaction solution, 1N hydrochloric acid was added, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was crystallized from n-hexane-ethyl acetate to obtain the title compound (222 g) as a colorless crystal.

Provenance & Evidence