Hydrochloric Acid → 3-(3-Cyano-4-hydroxy-5-trifluoromethylbenzoyl)-1-oxo-2,3-dihydro-1,3-benzothiazole

Participants

Reaction Conditions

Reaction Steps

3-(3-cyano-4-methoxy-5-trifluoromethylbenzoyl)-1-oxo-2,3-dihydro-1,3-benzothiazole (619 mg) was dissolved in N,N-dimethylformamide (5 mL), and lithium chloride (276 mg) was added to the solution, and the mixture was stirred at 70° C. for 3 hours. To the reaction solution, 1N hydrochloric acid was added, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (494 mg) as a colorless crystal.

Provenance & Evidence