HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385025Generated: October 31, 2026
Toluene → 3-Chloro-5-cyano-4-methoxybenzoyl chloride
https://huagongshe.com/reaction/385025
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 33779600 | HCID 33779600 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Chloro-5-cyano-4-methoxybenzoyl chloride | HCID 86668151 | — |
Reaction Steps
To 3-chloro-5-cyano-4-methoxybenzoic acid (932 mg), toluene (9.3 mL), N,N-dimethylformamide (0.03 mL) and thionyl chloride (0.38 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (993 mg) as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-61bffe82ad7f42468e8481776676bb3a |
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| Source note | uspto-grants-2013_02 |
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