Hydrochloric Acid → HCID 51349057, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-chloro-5-cyano-4-methoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (180 mg) was dissolved in N,N-dimethylformamide (2 mL), and lithium chloride (87 mg) was added to the solution, and then the mixture was stirred at 100° C. for 1 hour. To the reaction solution, 1N hydrochloric acid was added, and then reaction mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was crystallized from n-hexane-chloroform to obtain the title compound (146 mg) as a pale yellow crystal.

Provenance & Evidence