Hydrochloric Acid → 3-t-Butyl-5-cyano-4-methoxybenzoic acid

Participants

Reaction Steps

Methyl 3-t-butyl-5-cyano-4-methoxybenzoate (1.48 g) was dissolved in methanol (20 ml), tetrahydrofuran (5 mL) and water (5 mL), and lithium hydroxide monohydrate (753 mg) was added to the solution, and then the mixture was stirred at room temperature for 2 hours. To the reaction solution, 10% hydrochloric acid was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (1.18 g) as a pale yellow crystal.

Provenance & Evidence