HCID 86668160, compound → HCID 68108957, compound

Participants

Reaction Steps

Methyl 3-cyano-5-ethynyl-4-methoxybenzoate (475 mg) was dissolved in tetrahydrofuran (10 mL), and 5% palladium-carbon (150 mg) was added to the solution, and then the mixture was stirred under a hydrogen atmosphere at room temperature for 30 minutes. The reaction solution was filtered, and then the solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1) to obtain the title compound (480 mg) as a colorless crystal.

Provenance & Evidence