Hydrochloric Acid → HCID 51349184, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-cyano-5-ethyl-4-methoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (309 mg) was dissolved in N,N-dimethylformamide (3 mL), and lithium chloride (443 mg) was added to the solution, and then the mixture was stirred at 120° C. for 2.5 hours. To the reaction solution, 1N hydrochloric acid was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was crystallized from n-hexane-chloroform to obtain the title compound (257 mg) as a brown crystal.

Provenance & Evidence