Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 68108477 | HCID 68108477 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86668162 | HCID 86668162 | — |
Reaction Steps
To 3-cyano-5-cyclopropyl-4-methoxybenzoic acid (200 mg), toluene (2 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.10 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained resiue was azeotroped with toluene and used for the synthesis of (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367843B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-61dc30bb2440491c8f1e6ec259b65249 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
