Hydrochloric Acid → HCID 51349052, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-cyano-5-ethynyl-4-methoxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (197 mg) was dissolved in N,N-dimethylformamide (2 mL), and lithium chloride (239 mg) was added to the solution, and then the mixture was stirred at 100° C. for 1 hour. To the reaction solution, 1N hydrochloric acid was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1), and then crystallized from n-hexane-acetone to obtain the title compound (102 mg) as a pale yellow crystal.

Provenance & Evidence