HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385082Generated: October 30, 2026
Toluene → 3-Chloro-5-fluoro-4-methoxybenzoyl chloride
https://huagongshe.com/reaction/385082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-5-fluoro-4-methoxybenzoic acid | HCID 3862547 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Chloro-5-fluoro-4-methoxybenzoyl chloride | HCID 3739079 | — |
Reaction Steps
To 3-chloro-5-fluoro-4-methoxybenzoic acid (295 mg), toluene (3 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.15 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-6dc2a5260df94ceea39ec2486633e060 |
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| Source note | uspto-grants-2013_02 |
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