Lithium hydroxide, monohydrate → HCID 33779593, compound

Participants

Reaction Steps

Methyl 3-chloro-5-iodo-4-methoxybenzoate (2.96 g) was dissolved in tetrahydrofuran (23 mL) and water (7 mL), and lithium hydroxide monohydrate (1.52 g) was added to the solution, and then the mixture was stirred at room temperature for 19 hours. After the organic solvent was distilled off, the mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (2.74 g) as a colorless crystal.

Provenance & Evidence