Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 33779593 | HCID 33779593 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 33779668 | HCID 33779668 | — |
Reaction Steps
To 3-chloro-5-iodo-4-methoxybenzoic acid (2.74 g), toluene (27 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.76 mL) were added to the solution, and then the mixture was stirred at 60° C. for 15 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (3.05 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367843B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-a0fb80e666e140368881bcd456970460 |
|---|
| Source note | uspto-grants-2013_02 |
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