Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 68108601 | HCID 68108601 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86668169 | HCID 86668169 | — |
Reaction Steps
To 4-methoxy-3-methylsulfanyl-5-trifluoromethylbenzoic acid (277 mg), toluene (7 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.12 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (f).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367843B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-6355b0cf5fc84735a521f00df8883677 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
