Hydrochloric Acid → HCID 86668172, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-t-butyl-4-methoxy-5-methylsulfonylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (232 mg) was dissolved in N,N-dimethylformamide (5 mL), and lithium chloride (225 mg) was added to the solution, and then the mixture was stirred at 130° C. for 2 hours. To the reaction solution, 1N hydrochloric acid was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water, 1N hydrochloric acid and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (201 mg) as a colorless amorphous product.

Provenance & Evidence