Lithium hydroxide, monohydrate → HCID 68109007, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-benzyloxy-3-methoxy-5-trifluoromethylbenzoate (704 mg) was dissolved in tetrahydrofuran (6 mL) and water (2 mL), and lithium hydroxide monohydrate (333 mg) was added to the solution, and then the mixture was stirred at 60° C. for 3 hours. After the organic solvent was distilled off, the mixture was acidified with 1N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (606 mg) as a colorless crystal.

Provenance & Evidence