Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 68109007 | HCID 68109007 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86668173 | HCID 86668173 | — |
Reaction Steps
To 4-benzyloxy-3-methoxy-5-trifluoromethylbenzoic acid (601 mg), toluene (6 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (657 mg) as a yellow oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367843B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-084cdea924c04321a8411b2b9e7309d5 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
